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Hemodynamic Effects on Particle Targeting in the Arterial Bifurcation for Different Magnet Positions.

Authors
  • Bernad, Sandor I1
  • Susan-Resiga, Daniela2, 3
  • Bernad, Elena S4
  • 1 Centre for Fundamental and Advanced Technical Research, Romanian Academy-Timisoara Branch, Mihai Viteazul Str. 24, RO-300223 Timisoara, Romania. [email protected] , (Oman)
  • 2 Centre for Fundamental and Advanced Technical Research, Romanian Academy-Timisoara Branch, Mihai Viteazul Str. 24, RO-300223 Timisoara, Romania. , (Oman)
  • 3 Faculty of Physics, West University of Timisoara, Vasile Parvan Str. 1, RO-300222 Timisoara, Romania. , (Oman)
  • 4 University of Medicine and Pharmacy "Victor Babes" Timisoara, P-ta Eftimie Murgu 2, RO-300041 Timisoara, Romania. , (Oman)
Type
Published Article
Journal
Molecules
Publisher
MDPI AG
Publication Date
Jul 09, 2019
Volume
24
Issue
13
Identifiers
DOI: 10.3390/molecules24132509
PMID: 31324029
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The present study investigated the possibilities and feasibility of drug targeting for an arterial bifurcation lesion to influence the host healing response. A micrometer sized iron particle was used only to model the magnetic carrier in the experimental investigation (not intended for clinical use), to demonstrate the feasibility of the particle targeting at the lesion site and facilitate the new experimental investigations using coated superparamagnetic iron oxide nanoparticles. Magnetic fields were generated by a single permanent external magnet (ferrite magnet). Artery bifurcation exerts severe impacts on drug distribution, both in the main vessel and the branches, practically inducing an uneven drug concentration distribution in the bifurcation lesion area. There are permanently positioned magnets in the vicinity of the bifurcation near the diseased area. The generated magnetic field induced deviation of the injected ferromagnetic particles and were captured onto the vessel wall of the test section. To increase the particle accumulation in the targeted region and consequently avoid the polypharmacology (interaction of the injected drug particles with multiple target sites), it is critical to understand flow hemodynamics and the correlation between flow structure, magnetic field gradient, and spatial position.

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