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COX2/PTGS2 Expression Is Predictive of Response to Neoadjuvant Celecoxib in HER2-negative Breast Cancer Patients.

Authors
  • DE Cremoux, Patricia1, 2
  • Hamy, Anne-Sophie3
  • Lehmann-Che, Jacqueline4, 2
  • Scott, Véronique5
  • Sigal, Brigitte6
  • Mathieu, Marie-Christine7
  • Bertheau, Philippe2, 3, 5, 6, 7, 8
  • Guinebretière, Jean Marc9
  • Pierga, Jean Yves10, 11
  • Giacchetti, Sylvie12
  • Brain, Etienne13
  • Marty, Michel14
  • Asselain, Bernard15
  • Spyratos, Frédérique16
  • Bièche, Ivan16
  • 1 Molecular Oncology Unit, Assistance Publique-Hôpitaux de Paris, University Saint-Louis Hospital, Paris, France [email protected] , (France)
  • 2 University Paris-Diderot, Sorbonne Paris Cité, INSERM/CNRS UMR944/7212, Paris, France. , (France)
  • 3 PSL Research University, Translational Research Department INSERM U932, Immunity and Cancer, Residual Tumor & Response to Treatment Laboratory (RT2 Lab), Curie Institute, Paris, France. , (France)
  • 4 Molecular Oncology Unit, Assistance Publique-Hôpitaux de Paris, University Saint-Louis Hospital, Paris, France. , (France)
  • 5 Translational Research Laboratory, Gustave Roussy Cancer Center, Villejuif, France. , (France)
  • 6 Pathology Department, Curie Institute, Paris, France. , (France)
  • 7 Pathology Department, Gustave Roussy Cancer Center, Villejuif, France. , (France)
  • 8 Pathology Department, Assistance Publique-Hôpitaux de Paris, University Saint-Louis Hospital, Paris, France. , (France)
  • 9 Tumor Biology Department, Curie Institute, Saint-Cloud, France. , (France)
  • 10 Medical Oncology Department, Curie Institute, Paris, France. , (France)
  • 11 University Paris-Descartes, Sorbonne Paris Cité, Paris, France. , (France)
  • 12 Breast Disease Unit, Assistance Publique-Hôpitaux de Paris, University Saint-Louis Hospital, Paris, France. , (France)
  • 13 Medical Oncology Department, Curie Institute, Saint-Cloud, France. , (France)
  • 14 Centre for Therapeutic Innovations in Oncology and Hematology, Assistance Publique-Hôpitaux de Paris, Saint-Louis Hospital, Paris, France. , (France)
  • 15 UMR 8081 "IM4R", Université Paris Sud, Paris, France. , (France)
  • 16 Pharmacogenomics Unit, Curie Institute, Paris, France. , (France)
Type
Published Article
Journal
Anticancer Research
Publisher
International Institute of Anticancer Research
Publication Date
Mar 01, 2018
Volume
38
Issue
3
Pages
1485–1490
Identifiers
PMID: 29491076
Source
Medline
Keywords
License
Unknown

Abstract

COX2 overexpression is predictive of pCR in patients with celecoxib-treated tumors. The efficacy of celecoxib in breast cancer might be improved by quantification of COX2 gene expression.

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