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COX-2 specific inhibitor, NS-398, increases macrophage migration inhibitory factor expression and induces neuroendocrine differentiation in C4-2b prostate cancer cells.

Authors
Type
Published Article
Journal
Molecular medicine (Cambridge, Mass.)
Publication Date
Volume
7
Issue
12
Pages
850–860
Identifiers
PMID: 11876163
Source
Medline
License
Unknown

Abstract

These data suggest that COX-2 inhibition induces NF-kappa beta transcription factor activation, which subsequently induces pro-inflammatory protein expression (COX-2 and MIF) and neuroendocrine differentiation in the LNCaP C4-2b subline. These data provide further evidence that pro-inflammatory protein expression may play an important role in prostate cancer progression.

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