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COVID-19: Why does disease severity vary among individuals?

Authors
  • Samadizadeh, Saeed1, 2
  • Masoudi, Maha1, 2
  • Rastegar, Mostafa1, 2
  • Salimi, Vahid3
  • Shahbaz, Mahsa Bataghva4
  • Tahamtan, Alireza1, 2
  • 1 Infectious Diseases Research Centre, Golestan University of Medical Sciences, Gorgan, Iran
  • 2 Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
  • 3 Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • 4 Roberts Research Institute and School of Biomedical Engineering, Western University, London, Canada
Type
Published Article
Journal
Respiratory Medicine
Publisher
Elsevier Ltd.
Publication Date
Mar 05, 2021
Volume
180
Pages
106356–106356
Identifiers
DOI: 10.1016/j.rmed.2021.106356
PMCID: PMC7934673
Source
PubMed Central
Keywords
License
Unknown

Abstract

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for the current pandemic, coronavirus disease 2019 (COVID-19). While all people are susceptible to the SARS-CoV-2 infection, the nature and severity of the disease vary significantly among individuals and populations. Importantly, reported disease burdens and case fatality rates differ considerably from country to country. There are, however, still uncertainties about the severity of the disease among individuals or the reason behind a more severe disease in some cases. There is a strong possibility that the severity of this disease depends on a complicated interaction between the host, virus, and environment, which leads to different clinical outcomes. The objective of this article is to point out the essential influential factors related to the host, virus, and environment affecting the clinical outcome of COVID-19.

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