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COVID-19 vaccines: knowing the unknown

Authors
  • Lv, Huibin1
  • Wu, Nicholas C.2
  • Mok, Chris K. P.1
  • 1 HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
  • 2 Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Type
Published Article
Journal
European Journal of Immunology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jun 24, 2020
Volume
50
Issue
7
Pages
939–943
Identifiers
DOI: 10.1002/eji.202048663
PMID: 32437587
PMCID: PMC7280575
Source
PubMed Central
License
Unknown

Abstract

Vaccine development against SARS-CoV-2 has drawn attention around the globe due to the exploding pandemic. Although COVID-19 is caused by a new coronavirus, SARS-CoV-2, previous research on other coronavirus vaccines, such as FIPV, SARS and MERS, has provided valuable information for the rapid development of COVID-19 vaccine. However, important knowledge gaps remain – some are specific to SARS-CoV-2, others are fundamental to immunology and vaccinology. Here we discuss areas that need to be addressed for COVID-19 vaccine development, and what can be learned from examples of vaccine development in the past. Since the beginning of the outbreak, the research progress on COVID-19 has been remarkable. We are therefore optimistic about the rapid development of COVID-19 vaccine.

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