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COVID-19 vaccine: A recent update in pipeline vaccines, their design and development strategies.

Authors
  • Rawat, Kajal1
  • Kumari, Puja1
  • Saha, Lekha2
  • 1 Department of Pharmacology, Post Graduate Institute of Medical Education & Research (PGIMER), 4th Floor, Research Block B, Chandigarh, 160012, India. , (India)
  • 2 Department of Pharmacology, Post Graduate Institute of Medical Education & Research (PGIMER), 4th Floor, Research Block B, Chandigarh, 160012, India. Electronic address: [email protected] , (India)
Type
Published Article
Journal
European journal of pharmacology
Publication Date
Nov 25, 2020
Volume
892
Pages
173751–173751
Identifiers
DOI: 10.1016/j.ejphar.2020.173751
PMID: 33245898
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Coronavirus Disease 2019 named as COVID-19 imposing a huge burden on public health as well as global economies, is caused by a new strain of betacoronavirus named as SARS-CoV-2. The high transmission rate of the virus has resulted in current havoc which highlights the need for a fast and effective approach either to prevent or treat the deadly infection. Development of vaccines can be the most prominent approach to prevent the virus to cause COVID-19 and hence will play a vital role in controlling the spread of the virus and reducing mortality. The virus uses its spike proteins for entering into the host by interacting with a specific receptor called angiotensin converting enzyme-2 (ACE2) present on the surface of alveolar cells in the lungs. Researchers all over the world are targeting the spike protein for the development of potential vaccines. Here, we discuss the immunopathological basis of vaccine designing that can be approached for vaccine development against SARS-CoV-2 infection and different platforms that are being used for vaccine development. We believe this review will increase our understanding of the vaccine designing against SARS-CoV-2 and subsequently contribute to the control of SARS-CoV-2 infections. Also, it gives an insight into the current status of vaccine development and associated outcomes reported at different phases of trial. Copyright © 2020 Elsevier B.V. All rights reserved.

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