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COVID-19 in a temporal relation to the onset of multiple sclerosis

Authors
  • Fragoso, Yara D.1, 2
  • Pacheco, Filippe A.S.3, 4
  • Silveira, Guilherme L.5
  • Oliveira, Rodrigo A.5
  • Carvalho, Vitor M.2, 4
  • Martimbianco, Ana Luiza C.1
  • 1 Professor of the Postgraduate Program for Health and Environment, Universidade Metropolitana de Santos, Santos, SP, Brazil
  • 2 MS & Headache Research, Santos, SP, Brazil
  • 3 Filippe Pacheco Clinic, Santos, SP, Brazil
  • 4 Postgraduate Program for Health and Environment, Universidade Metropolitana de Santos, Santos, SP, Brazil
  • 5 Mega Imagem, Santos, SP, Brazil
Type
Published Article
Journal
Multiple Sclerosis and Related Disorders
Publisher
Elsevier B.V.
Publication Date
Feb 24, 2021
Volume
50
Pages
102863–102863
Identifiers
DOI: 10.1016/j.msard.2021.102863
PMID: 33662859
PMCID: PMC7902206
Source
PubMed Central
Keywords
Disciplines
  • Correspondence
License
Unknown

Abstract

Neurological complications of COVID-19 have been described. We present the case of a 27-year-old woman who developed COVID-19 in April 2020. She continued to present anosmia and ageusia eight months later. Six months after contracting COVID-19, she developed dysesthesia, hypoesthesia and hyperreflexia. Her magnetic resonance imaging showed demyelinating lesions, of which two were enhanced by gadolinium. She was positive for oligoclonal bands in her spinal fluid. This patient developed multiple sclerosis with a temporal relationship to COVID-19. We believe that SARS-CoV-2 led to her autoimmune disease through a virus-induced neuroimmunopathological condition.

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