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COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome

Authors
  • Hirano, Toshio1, 2
  • Murakami, Masaaki2
  • 1 Headquarters, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan
  • 2 Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-0815, Japan
Type
Published Article
Journal
Immunity
Publication Date
Apr 22, 2020
Volume
52
Issue
5
Pages
731–733
Identifiers
DOI: 10.1016/j.immuni.2020.04.003
PMID: 32325025
PMCID: PMC7175868
Source
PubMed Central
License
Unknown

Abstract

Understanding the cell entry mechanism of pandemic coronavirus SARS-CoV-2 is crucial for treating the disease. Zhou et al. ( Nature ) and Hoffmann et al. ( Cell ) identify ACE2 as a SARS-CoV-2 receptor, and the latter show its entry mechanism depends on cellular serine protease TMPRSS2. These results suggest several possible therapeutic targets, including the IL-6-STAT3 axis previously associated with cytokine release syndromes.

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