Understanding the cell entry mechanism of pandemic coronavirus SARS-CoV-2 is crucial for treating the disease. Zhou et al. ( Nature ) and Hoffmann et al. ( Cell ) identify ACE2 as a SARS-CoV-2 receptor, and the latter show its entry mechanism depends on cellular serine protease TMPRSS2. These results suggest several possible therapeutic targets, including the IL-6-STAT3 axis previously associated with cytokine release syndromes.