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COVID-19 neutralizing antibody-based therapies in humoral immune deficiencies: A narrative review.

Authors
  • Focosi, Daniele1
  • Franchini, Massimo2
  • 1 North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy. , (Italy)
  • 2 Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantua, Italy. Electronic address: [email protected] , (Italy)
Type
Published Article
Journal
Transfusion and Apheresis Science
Publisher
Elsevier
Publication Date
Jun 01, 2021
Volume
60
Issue
3
Pages
103071–103071
Identifiers
DOI: 10.1016/j.transci.2021.103071
PMID: 33518427
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), generated an unprecedented global health and social emergency. Despite many efforts from clinicians to develop effective anti-COVID-19 treatment protocols, no specific therapy is currently available. Among anti-viral agents, convalescent plasma (CP) from recovered patients is the object of intense research following the first positive reports in severe COVID-19 patients. Passive immunotherapy the rationale to provide higher benefits in COVID-19 patients with humoral immune deficiencies, such as those with solid and hematologic cancers, patients with primary and acquired immunodeficiencies, and recipients of solid organ and hematopoietic stem cell transplants. The aim of this narrative review will be to critically discuss the literature evidence on CP use in these categories of patients. Copyright © 2021 Elsevier Ltd. All rights reserved.

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