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COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor.

Authors
  • Mjaess, G1
  • Karam, A2
  • Aoun, F3
  • Albisinni, S4
  • Roumeguère, T5
  • 1 Urology Department, University Clinics of Brussels, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium; Hotel-Dieu de France, University of Saint-Joseph, Beirut, Lebanon. , (Belgium)
  • 2 Hotel-Dieu de France, University of Saint-Joseph, Beirut, Lebanon. , (France)
  • 3 Hotel-Dieu de France, University of Saint-Joseph, Beirut, Lebanon; Urology Department, Institut Jules-Bordet, Brussels, Belgium. , (Belgium)
  • 4 Urology Department, University Clinics of Brussels, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. , (Belgium)
  • 5 Urology Department, University Clinics of Brussels, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium; Urology Department, Institut Jules-Bordet, Brussels, Belgium. Electronic address: [email protected] , (Belgium)
Type
Published Article
Journal
Progrès en Urologie
Publisher
Elsevier
Publication Date
Sep 01, 2020
Volume
30
Issue
10
Pages
484–487
Identifiers
DOI: 10.1016/j.purol.2020.05.007
PMID: 32620366
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

COVID-19 is the pandemic that hit the world starting December 2019. Recent studies and international statistics have shown an increased prevalence, morbidity as well as mortality of this disease in male patients compared to female patients. The aim of this brief communication is to describe the pathophysiology of this sex-discrepancy, based on the infectivity mechanism of the coronavirus including the Angiotensin-Converting Enzyme 2 (ACE2), the Type II transmembrane Serine Protease (TMPRSS2), and the androgen receptor. This could help understand the susceptibility of urological patients, especially those receiving androgen deprivation therapy for prostate cancer, and testosterone replacement therapy. Copyright © 2020 Elsevier Masson SAS. All rights reserved.

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