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COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses

Authors
  • Bonifacius, Agnes1
  • Tischer-Zimmermann, Sabine1
  • Dragon, Anna C.1
  • Gussarow, Daniel1
  • Vogel, Alexander1
  • Krettek, Ulrike1
  • Gödecke, Nina1
  • Yilmaz, Mustafa2
  • Kraft, Anke R.M.3, 4, 5
  • Hoeper, Marius M.6
  • Pink, Isabell6
  • Schmidt, Julius J.7
  • Li, Yang8
  • Welte, Tobias6
  • Maecker-Kolhoff, Britta9
  • Martens, Jörg1
  • Berger, Marc Moritz10
  • Lobenwein, Corinna11
  • Stankov, Metodi V.4, 12
  • Cornberg, Markus3, 4, 5
  • And 5 more
  • 1 Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany
  • 2 Public Health Department, Hannover, Germany
  • 3 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
  • 4 German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Germany
  • 5 Centre for Individualised Infection Medicine (CiiM), Hannover, Germany
  • 6 Department of Pneumology, Hannover Medical School, member of the German Centre for Lung Research (DZL), Hannover, Germany
  • 7 Department of Kidney and Hypertension Diseases, Hannover Medical School, Hannover, Germany
  • 8 Department Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine (CiiM), Helmholtz Centre for Infection Research, Hannover Medical School, Hannover, Germany
  • 9 Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
  • 10 Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, Essen, Germany
  • 11 Department of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Germany
  • 12 Department of Rheumatology and Clinical Immunology, Hannover Medical School, Hannover, Germany
  • 13 Institute of Intensive Care Medicine, University Hospital Zurich, Switzerland
Type
Published Article
Journal
Immunity
Publication Date
Feb 09, 2021
Volume
54
Issue
2
Pages
340–354
Identifiers
DOI: 10.1016/j.immuni.2021.01.008
PMID: 33567252
PMCID: PMC7871825
Source
PubMed Central
Keywords
License
Unknown

Abstract

COVID-19 varies from asymptomatic infection to multiorgan failure, but data on cellular immunity against SARS-CoV-2 during disease and beyond are lacking. Bonifacius et al. show a beneficial effect of preexisting immunity to endemic coronaviruses during disease and stable cellular immunity with concomitant decrease of humoral responses early during convalescence.

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