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COVID-19 and the Coombs test

Authors
  • Hendrickson, Jeanne E.
  • Tormey, Christopher A.
Type
Published Article
Journal
Blood
Publisher
American Society of Hematology
Publication Date
Aug 06, 2020
Volume
136
Issue
6
Pages
655–656
Identifiers
DOI: 10.1182/blood.2020007483
PMID: 32761221
PMCID: PMC7414592
Source
PubMed Central
License
Green

Abstract

In this issue of Blood , Berzuini et al 1 describe immunoglobulin G (IgG) bound to the red blood cells (RBCs) of patients with COVID-19 and associate this bound IgG with increased RBC transfusion requirements. The intrigue behind these observations is not just the high (46%) direct antiglobulin test (DAT) positivity rate, but also the novel finding that eluates (ie, antibodies stripped from the surface of the reactive RBCs) from these DAT-positive patients react not with standard-reagent RBCs but exclusively with RBCs from DAT-negative COVID-19 patients.

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