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COVID-19 in chronic kidney disease: a retrospective, propensity score-matched cohort study.

Authors
  • Dirim, Ahmet Burak1
  • Demir, Erol2
  • Yadigar, Serap3
  • Garayeva, Nurana2
  • Parmaksiz, Ergun3
  • Safak, Seda2
  • Bahat, Kubra Aydin3
  • Ucar, Ali Riza2
  • Oruc, Meric3
  • Oto, Ozgur Akin2
  • Medetalibeyoglu, Alpay4
  • Basaran, Seniha5
  • Orhun, Gunseli6
  • Yazici, Halil2
  • Turkmen, Aydin2
  • 1 Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. [email protected] , (Turkey)
  • 2 Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. , (Turkey)
  • 3 Division of Nephrology, Department of Internal Medicine, Dr. Lutfi Kirdar Kartal Teaching and Research Hospital, Istanbul, Turkey. , (Turkey)
  • 4 Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. , (Turkey)
  • 5 Department of Infectious Diseases and Clinical Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. , (Turkey)
  • 6 Department of Anesthesiology and Intensive Care, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. , (Turkey)
Type
Published Article
Journal
International Urology and Nephrology
Publisher
Springer-Verlag
Publication Date
Oct 01, 2021
Volume
53
Issue
10
Pages
2117–2125
Identifiers
DOI: 10.1007/s11255-021-02783-0
PMID: 33548044
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The prognostic factors for COVID-19 in patients with chronic kidney disease (CKD) are uncertain. We conducted a study to compare clinical and prognostic features between hospitalized COVID-19 patients with and without CKD. Fifty-six patients with stage 3-5 CKD and propensity score-matched fifty-six patients without CKD were included in the study. Patients were followed-up at least fifteen days or until death after COVID-19 diagnosis. The endpoints were death from all causes, development of acute kidney injury (AKI) or cytokine release syndrome or respiratory failure, or admission to the intensive care unit (ICU). All patients were reviewed retrospectively over a median follow-up of 44 days (IQR, 36-52) after diagnosis of COVID-19. Patients with CKD had higher intensive care unit admission and mortality rates than the patients without CKD, but these results did not reach statistical significance (16 vs. 19; p = 0.54 and 11 vs. 16, p = 0.269, respectively). The frequency of AKI development was significantly higher in predialysis patients with CKD compared to the other group (8 vs. 5; p < 0.001), but there was no significant difference between the groups in terms of cytokine release syndrome (13 vs. 8; p = 0.226), follow-up in the ICU (19 vs. 16; p = 0.541), and respiratory failure (25 vs. 22, p = 0.566). Multivariate logistic regression analysis revealed that respiratory failure and AKI were independent risk factors for mortality. The mortality rates of COVID-19 patients with CKD had higher than COVID-19 patients without CKD. Also, AKI and respiratory failure were independently related to mortality. © 2021. The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.

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