Affordable Access

Access to the full text

Counterbalancing anti-adhesive effects of Tenascin-C through fibronectin expression in endothelial cells

Authors
  • Radwanska, Agata1
  • Grall, Dominique1
  • Schaub, Sébastien1
  • Divonne, Stéphanie Beghelli-de la Forest...1, 2
  • Ciais, Delphine1
  • Rekima, Samah1
  • Rupp, Tristan3, 4
  • Sudaka, Anne1, 2
  • Orend, Gertraud3, 4
  • Van Obberghen-Schilling, Ellen1, 2
  • 1 Université Côte d’Azur, CNRS, INSERM, iBV, France , INSERM, iBV (France)
  • 2 Centre Antoine Lacassagne, Nice, 06189, France , Nice (France)
  • 3 Inserm, U1109, MN3T laboratory, The Microenvironmental Niche in Tumorigenesis and Targeted Therapy, Strasbourg, F-67000, France , Strasbourg (France)
  • 4 University Strasbourg, Strasbourg, F-67000, France , Strasbourg (France)
Type
Published Article
Journal
Scientific Reports
Publisher
Springer Nature
Publication Date
Oct 06, 2017
Volume
7
Issue
1
Identifiers
DOI: 10.1038/s41598-017-13008-9
Source
Springer Nature
License
Green

Abstract

Cellular fibronectin (FN) and tenascin-C (TNC) are prominent development- and disease-associated matrix components with pro- and anti-adhesive activity, respectively. Whereas both are present in the tumour vasculature, their functional interplay on vascular endothelial cells remains unclear. We have previously shown that basally-oriented deposition of a FN matrix restricts motility and promotes junctional stability in cultured endothelial cells and that this effect is tightly coupled to expression of FN. Here we report that TNC induces FN expression in endothelial cells. This effect counteracts the potent anti-adhesive activity of TNC and leads to the assembly of a dense highly-branched subendothelial matrix that enhances tubulogenic activity. These findings suggest that pro-angiogenic remodelling of the perivascular matrix may involve TNC-induced upregulation of FN in endothelial cells.

Report this publication

Statistics

Seen <100 times