Counteracting in Vitro Toxicity of the Ionophoric Mycotoxin Beauvericin-Synthetic Receptors to the Rescue.
Organic and Biomimetic Chemistry Research Group, Department of Organic and Macromolecular Chemistry , Ghent University , Krijgslaan 281 , 9000 Ghent , Belgium.
Department of Bioanalysis, Laboratory of Food Analysis , Ghent University , Ottergemsesteenweg 460 , 9000 Ghent , Belgium.
- Published Article
The Journal of Organic Chemistry
American Chemical Society
- Publication Date
Aug 16, 2019
Beauvericin (BEA) and enniatins are toxic ionophoric cyclodepsipeptides that mainly occur in grains. As such, their presence in food commodities poses a concern for public health. To date, despite recent European Food Safety Authority emphasis on the need for more data to evaluate long-term toxicity effects, no suitable affinity reagents are available to detect the presence of BEA and derivatives in food samples. We here report on the synthesis of a small library of artificial receptors with varying cavity sizes and different hydrophobic building blocks. Immobilization of one of the receptors on solid support resulted in a strong retention of beauvericin, thus revealing promising properties as solid-phase extraction material for sample pretreatment. Furthermore, treatment of HepG2 cells with the most promising receptor markedly reduced beauvericin-induced cytotoxicity, hinting toward the possibility of using synthetic receptors as antidotes against ionophoric toxins.
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This record was last updated on 12/25/2021 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/31393120