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Could computed tomography be used as a surrogate of endoscopic ultrasonography in the screening and surveillance of small gastric Gastrointestinal stromal tumors?

Authors
  • Jia, Xiaoxuan1
  • Liu, Yiting2
  • Zhao, Jiaqi1
  • Ji, Wanying2
  • Tang, Lei2
  • Gao, Zhidong3
  • Zhang, Liming4
  • Zhang, Yinli5
  • Li, Jian6
  • Hong, Nan1
  • Wang, Yi7
  • Sun, Yingshi8
  • 1 Department of Radiology, Peking University People's Hospital, Beijing, 100044, China. , (China)
  • 2 Department of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China. , (China)
  • 3 Department of Gastrointestinal Surgery, Peking University People's Hospital, Beijing, 100044, China. , (China)
  • 4 Department of Gastroenterology, Peking University People's Hospital, Beijing, 100044, China. , (China)
  • 5 Department of Pathology, Peking University People's Hospital, Beijing, 100044, China. , (China)
  • 6 Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China. , (China)
  • 7 Department of Radiology, Peking University People's Hospital, Beijing, 100044, China. Electronic address: [email protected] , (China)
  • 8 Department of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
European journal of radiology
Publication Date
Dec 02, 2020
Volume
135
Pages
109463–109463
Identifiers
DOI: 10.1016/j.ejrad.2020.109463
PMID: 33338760
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To investigate whether computed tomography (CT) could be used for screening and surveillance of small gastric gastrointestinal stromal tumors (gGISTs). A total of 162 pathologically confirmed small gGISTs (≤2 cm) between September 2007 and November 2019 were retrospectively enrolled. Thirty-six lesions received contrast-enhanced CT after they were identified by endoscopy and EUS, and forty-three lesions received CT alone before surgery. The detection rate of CT for ≤1 cm gGISTs (micro-gGISTs) and 1-2 cm gGISTs (mini-gGISTs) was investigated, and the detection rate of CT alone was compared with that of CT following endoscopy and EUS. The relationship between EUS- and CT-detected high-risk features were assessed. CT demonstrated a favorable detection rate for mini-gGISTs previously identified by EUS and endoscopy, whereas CT alone showed an inferior detection rate (100 % vs. 75 %, p = 0.02). CT showed a poor detection rate for micro-gGISTs, both for lesions received CT after identified by EUS and endoscopy, and those received CT alone (33.3 % vs. 14.8 %, p = 0.372). CT-detected heterogeneous enhancement pattern and presence of calcification were strongly correlated with heterogeneous echotexture (Spearman's ρ=0.66, p < 0.001) and echogenic foci (Spearman's ρ=0.79, p < 0.001) on EUS, respectively. CT-detected necrosis was moderately correlated with cystic spaces on EUS (Spearman's ρ=0.42, p = 0.02). No correlation was found between EUS- and CT- assessed irregular border. CT could potentially be considered as a surrogate of EUS for surveillance of mini-gGISTs instead of micro-gGISTs, whereas couldn't be used as a screening modality for either micro- or mini-gGISTs. Copyright © 2020 Elsevier B.V. All rights reserved.

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