Affordable Access

Access to the full text

Could both intrinsic and extrinsic iodine be successfully suppressed on virtual non-contrast CT images for detecting thyroid calcification?

Authors
  • Park, Arim1, 2
  • Lee, Young Hen1
  • Seo, Hyung Suk1
  • 1 Korea University College of Medicine, 123, Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, 15355, Republic of Korea , Ansan-si (South Korea)
  • 2 Sungkyunkwan University School of Medicine, Seoul, Republic of Korea , Seoul (South Korea)
Type
Published Article
Journal
Japanese Journal of Radiology
Publisher
Springer Singapore
Publication Date
Jan 28, 2021
Volume
39
Issue
6
Pages
580–588
Identifiers
DOI: 10.1007/s11604-021-01095-8
Source
Springer Nature
Keywords
License
Yellow

Abstract

PurposeAlthough virtual non-contrast (VNC) successfully removes iodinated contrast, uncertainty exists regarding the feasibility of VNC to suppress iodine for detecting thyroid calcification. Therefore, we evaluated whether both intrinsic and extrinsic iodine attenuation were suppressed on VNC images.Material and methodsWe enrolled 128 patients (male: female 17:111; age 48.0 ± 10.4 years) who underwent dual-layer dual-energy CT (DL-DECT) examination before their thyroid cancer surgeries. Two additional sets of VNC (VNCu, VNCc) images were retrospectively generated from their true unenhanced (TUE) and true contrast-enhanced (TCE) series. We compared CT attenuation values measured on the VNCu and VNCc images by drawing identical regions of interest encompassing thyroid parenchyma, then subjectively determined the concordance of calcification.ResultsAlthough CT attenuation discrepancies between the VNCu and VNCc were significant (2.0 ± 5.7HU, p < 0.001),61.7%, 89.1%, and 100.0% of all measurements were < 5HU, < 10HU, and < 15HU. Based on Bland–Altman analysis, the limits of agreement were − 9.2HU and 13.2HU, whereas the proportional differences were small for VNC images generated from both TUE and TCE images. There was no discordance between two VNC image sets in detecting thyroid calcification.ConclusionsVNC technique could be a feasible method to suppress both intrinsic and extrinsically administered iodine for detecting thyroid calcification

Report this publication

Statistics

Seen <100 times