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Cotranslational protein folding--fact or fiction?

Authors
  • Deane, Charlotte M
  • Dong, Mingqiang
  • Huard, Fabien P E
  • Lance, Braddon K
  • Wood, Graham R
Type
Published Article
Journal
Bioinformatics (Oxford, England)
Publication Date
Jul 01, 2007
Volume
23
Issue
13
Identifiers
PMID: 17646290
Source
Medline
License
Unknown

Abstract

We explore computationally the existence of evidence for cotranslational folding, based on large sets of experimentally determined structures in the PDB. Our perspective is that cotranslational folding is the norm, but that the effect is masked in most classes. We show that it is most evident in alpha/beta proteins, confirming recent findings. We also find mild evidence that older proteins may fold cotranslationally. A tool is provided for determining, within a protein, where cotranslation is most evident.

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