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Costimulation couture: a designer approach to regulating autoimmunity.

Authors
Type
Published Article
Journal
The Journal of clinical investigation
Publication Date
Volume
116
Issue
8
Pages
2080–2083
Identifiers
PMID: 16886054
Source
Medline
License
Unknown

Abstract

Negative or inhibitory costimulatory pathways regulate T cell activation and play a role in peripheral tolerance. Targeting these pathways harnesses the physiologic mechanisms of regulating autoimmunity and could prove beneficial for the therapy of autoimmune diseases. However, attempts at targeting these pathways have been fraught with difficulties. In this issue of the JCI, Fife et al. describe a creative approach for targeting CTL-associated antigen 4 (CTLA-4) on activated T cells via genetically engineered B cells to prevent autoimmune diabetes in the NOD mouse (see the related article beginning on page 2252). Novel "designer" strategies targeting negative costimulatory pathways provide reasons for optimism in the search for a cure for devastating autoimmune diseases.

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