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Cost analysis of skeletal-related events in Spanish patients with bone metastases from solid tumours

  • Durán, I.1, 2
  • Garzón, C.3
  • Sánchez, A.4
  • García-Carbonero, I.5
  • Pérez-Gracia, J. L.6
  • Seguí-Palmer, M. Á.7
  • Wei, R.8
  • Restovic, G.9
  • Gasquet, J. A.10
  • Gutiérrez, L.11
  • 1 Centro Integral Oncológico Clara Campal (CIOCC), Madrid, Spain , Madrid (Spain)
  • 2 Hospital Universitario Virgen del Rocio, Unidad Gestion Clinica Oncologia Integral, Avda Manuel Siurot s/n, Sevilla, 41013, Spain , Sevilla (Spain)
  • 3 Instituto Catalán Oncología ICO-IDIBELL, Barcelona, Spain , Barcelona (Spain)
  • 4 Hospital Universitario Puerta de Hierro, Madrid, Spain , Madrid (Spain)
  • 5 Hospital Virgen de La Salud, Toledo, Spain , Toledo (Spain)
  • 6 Clínica Universitaria de Navarra, Pamplona, Spain , Pamplona (Spain)
  • 7 Corporació Sanitària Parc Taulí, Sabadell, Spain , Sabadell (Spain)
  • 8 Amgen Inc, Biostatistics, Thousand Oaks, CA, USA , Thousand Oaks (United States)
  • 9 Amaris Consultancy, Health Economics, Barcelona, Spain , Barcelona (Spain)
  • 10 Amgen S.A, Medical Department, Barcelona, Spain , Barcelona (Spain)
  • 11 Amgen S.A, Pharmacoeconomics and Health Outcomes Research Department, Barcelona, Spain , Barcelona (Spain)
Published Article
Clinical & Translational Oncology
Publication Date
Aug 13, 2013
DOI: 10.1007/s12094-013-1077-2
Springer Nature


PurposeTo estimate the cost per skeletal-related event (SRE) in patients with bone metastases secondary to solid tumours in the Spanish healthcare setting.MethodsPatients diagnosed with bone metastases secondary to breast, prostate or lung cancer were included in this multicentre, observational study. SREs are defined as pathologic fracture (vertebral and non-vertebral fracture), radiation to bone, spinal cord compression or surgery to bone. Health resource utilisation associated with these events (inpatient stays, outpatient, emergency room and home health visits, nursing home stays and procedures) were collected retrospectively for all SREs that occurred in the 97 days prior to enrolment and prospectively during follow-up. Unit costs were obtained from the 2010 eSalud healthcare costs database.ResultsA total of 93 Spanish patients with solid tumours were included (31 had breast cancer, 21 prostate cancer and 41 lung cancer), contributing a total of 143 SREs to this cost analysis. Inpatient stays (between 9.0 and 29.9 days of mean length of stay per inpatient stay by SRE type) and outpatient visits (between 1.7 and 6.4 mean visits per SRE type) were the most frequently reported types of health resources utilised. The mean cost per SRE was between €2,377.79 (radiation to bone) and €7,902.62 (spinal cord compression).ConclusionSREs are associated with a significant consumption of healthcare resources that generate a substantial economic burden for the Spanish healthcare system.

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