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Cortisol profiles differentiated in adolescents and young adult males with fragile X syndrome versus autism spectrum disorder.

Authors
  • Matherly, Sara M1
  • Klusek, Jessica2
  • Thurman, Angela J3
  • McDuffie, Andrea3
  • Abbeduto, Leonard3
  • Roberts, Jane E1
  • 1 Department of Psychology, University of South Carolina, Columbia, South Carolina.
  • 2 Department of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina.
  • 3 Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California, Davis, Sacramento, California.
Type
Published Article
Journal
Developmental Psychobiology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 24, 2017
Identifiers
DOI: 10.1002/dev.21578
PMID: 29171019
Source
Medline
Keywords
License
Unknown

Abstract

Taken together, findings suggest a unique neuroendocrine profile that distinguishes adolescent/young adult males with FXS from those with non-syndromic ASD. Severity of ASD symptoms appears to be related to cortisol reactivity in the non-syndromic ASD sample, but not in FXS; while anxiety symptoms are associated with HPA activation in the FXS sample, but not in ASD despite a high prevalence of ASD, anxiety and physiological dysregulation characteristic in both populations.

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