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Cortisol and dexamethasone elimination during treatment with cimetidine.

Authors
Type
Published Article
Journal
British Journal of Clinical Pharmacology
0306-5251
Publisher
Wiley Blackwell (Blackwell Publishing)
Publication Date
Volume
18
Issue
1
Pages
101–103
Identifiers
PMID: 6743481
Source
Medline

Abstract

In a randomised cross-over study of treatment for 7 days with cimetidine 600 mg twice daily and placebo, cimetidine had no effect on the pharmacokinetics of a single intravenous dose of dexamethasone sodium phosphate. Likewise the elimination characteristics of endogenous cortisol in the dexamethasone suppressed state were not affected by cimetidine.

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