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Cortisol and dexamethasone elimination during treatment with cimetidine.

Authors
  • Peden, N R
  • Rewhorn, I
  • Champion, M C
  • Mussani, R
  • Ooi, T C
Type
Published Article
Journal
British journal of clinical pharmacology
Publication Date
Jul 01, 1984
Volume
18
Issue
1
Pages
101–103
Identifiers
PMID: 6743481
Source
Medline
License
Unknown

Abstract

In a randomised cross-over study of treatment for 7 days with cimetidine 600 mg twice daily and placebo, cimetidine had no effect on the pharmacokinetics of a single intravenous dose of dexamethasone sodium phosphate. Likewise the elimination characteristics of endogenous cortisol in the dexamethasone suppressed state were not affected by cimetidine.

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