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Cortical activity measured by functional near infrared spectroscopy during a theory of mind task in subjects with schizophrenia, bipolar disorder and healthy controls.

Authors
  • Sayar-Akaslan, Damla1
  • Baskak, Bora2
  • Kir, Yagmur1
  • Kusman, Adnan1
  • Yalcinkaya, Busra1
  • Çakmak, Işık Batuhan3
  • Munir, Kerim4
  • 1 Ankara University, Faculty of Medicine, Department of Psychiatry, Ankara University Brain Research Center (AUBAUM), Ankara, Turkey. , (Turkey)
  • 2 Ankara University, Faculty of Medicine, Department of Psychiatry, Ankara University Brain Research Center (AUBAUM), Ankara, Turkey; Neuroscience and Neurotechnology Center of Excellence, NÖROM, Ankara, Turkey. Electronic address: [email protected] , (Turkey)
  • 3 University of Health Sciences, Ankara City Hospital, Department of Psychiatry, Turkey. , (Turkey)
  • 4 Harvard Medical School, Developmental Medicine Center, Boston Children's Hospital, Boston, USA.
Type
Published Article
Journal
Journal of affective disorders
Publication Date
Mar 01, 2021
Volume
282
Pages
329–339
Identifiers
DOI: 10.1016/j.jad.2020.12.094
PMID: 33421860
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Theory of Mind (ToM) deficits interfere in social cognitive functioning in schizophrenia (SCZ) and are increasingly recognized to do so in bipolar disorder (BD), however their clinical and neurobiological correlates remain unclear. This study represents the first direct comparison of subjects with SCZ (N = 26), BD (N = 26) and healthy controls (N = 33) in cortical activity during the Reading the Mind in the Eyes Task (RMET) using functional Near Infrared Spectroscopy (fNIRS) with the control condition (CC) involving gender identification via the same stimuli. The three groups were compared with a comprehensive ToM battery and assessed in terms of the relationship of ToM performance with clinical symptoms, insight and functioning. The controls scored higher than the SCZ and BD groups in ToM assessments, with SCZ group showing the worse performance in terms of meta-representation and empathy. The SCZ group ToM scores inversely correlated with negative symptom severity and positively correlated with insight; BD group ToM scores negatively correlated with subclinical mania symptoms and projected functioning. Cortical activity was higher during the ToM condition compared to the CC in the pre-motor and supplementary-motor cortices, middle and superior temporal gyri, and the primary somatosensory cortex. Group x Condition interaction was detected whereby activity was higher during the ToM condition among controls with no detected difference between SCZ and BD groups. The results suggest that ToM is represented similarly in cortical activity in SCZ and BD compared to healthy controls pointing to possible neurobiological convergence of SCZ and BD in underlying impairments of social cognition. Copyright © 2020. Published by Elsevier B.V.

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