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Correlations Between Clinical Trial Outcomes Based on Symptoms, Functional Impairments, and Quality of Life in Children and Adolescents With ADHD.

Authors
  • Coghill, David R1, 2
  • Joseph, Alain3
  • Sikirica, Vanja4
  • Kosinski, Mark5
  • Bliss, Caleb6
  • Huss, Michael7
  • 1 1 University of Melbourne, Victoria, Australia. , (Australia)
  • 2 2 University of Dundee, UK.
  • 3 3 Shire, Zug, Switzerland. , (Switzerland)
  • 4 4 Shire, Wayne, PA, USA.
  • 5 5 QualityMetric Inc., Lincoln, RI, USA.
  • 6 6 Shire, Lexington, MA, USA.
  • 7 7 Johannes Gutenberg University Mainz, Germany. , (Germany)
Type
Published Article
Journal
Journal of Attention Disorders
Publisher
SAGE Publications
Publication Date
Nov 01, 2019
Volume
23
Issue
13
Pages
1578–1591
Identifiers
DOI: 10.1177/1087054717723984
PMID: 28836895
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To assess relationships between treatment-associated changes in measures of ADHD symptoms, functional impairments, and health-related quality of life in children and adolescents with ADHD. Pearson correlation coefficients were calculated post hoc for changes from baseline to endpoint in outcomes of one randomized, placebo- and active-controlled trial of lisdexamfetamine (osmotic-release methylphenidate reference) and one of guanfacine extended-release (atomoxetine reference). Changes in ADHD Rating Scale IV (ADHD-RS-IV) total score generally correlated moderately with changes in Child Health and Illness Profile-Child Edition: Parent Report Form (CHIP-CE:PRF) Achievement and Risk Avoidance ( r ≈ .4), but weakly with Resilience, Satisfaction, and Comfort ( r ≈ .2); and moderately with Weiss Functional Impairment Rating Scale-Parent (WFIRS-P) total score ( r ≈ .5). PRF Achievement and Risk Avoidance correlated moderately to strongly with WFIRS-P total score ( r ≈ .6). The ADHD-RS-IV, CHIP-CE:PRF, and WFIRS-P capture distinct but interconnected aspects of treatment response in individuals with ADHD.

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