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Correlation of type A behaviour with adrenergic receptor density: implications for coronary artery disease pathogenesis.

Authors
Type
Published Article
Journal
Lancet (London, England)
Publication Date
Volume
2
Issue
8565
Pages
937–939
Identifiers
PMID: 2889863
Source
Medline
License
Unknown

Abstract

In 17 healthy young men who had a parent with documented early coronary disease, ratings of type A behaviour correlated with upregulated lymphocyte beta 2 receptor density and inversely with the ratio of platelet alpha 2 to lymphocyte beta 2 receptor density ratio. This indicates a correlation of type A behaviour with receptor-based determinations of increased peripheral alpha-adrenergic balance, consistent with increased coronary arterial vasoconstriction, perhaps leading to coronary artery disease.

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