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Correlation of tolerogenicity of a viral antigen with its immunogenicity.

Authors
  • Bachmann, M F
  • Fehr, T
  • Freer, G
  • Hengartner, H
  • Zinkernagel, R M
Type
Published Article
Journal
Journal of immunology (Baltimore, Md. : 1950)
Publication Date
Jun 01, 1997
Volume
158
Issue
11
Pages
5106–5111
Identifiers
PMID: 9164925
Source
Medline
License
Unknown

Abstract

Induction of B cell tolerance or activation was analyzed with vesicular stomatitis virus (VSV) glycoprotein (G) expressed as a neo-self Ag. A membrane form of VSV-G expressed in all tissues, including the bone marrow, induced unresponsiveness at both the Th and B cell level, whereas a soluble form of VSV-G expressed peripherally in liver and kidney did not tolerize B cells and only reversibly anergized Th cells. Interestingly, a similar correlation was found for activation of mature lymphocytes. When mature normal spleen cells were transferred into the two transgenic mouse lines, the membrane form of VSV-G was strongly immunogenic for both Th and B cells, and high VSV-G-specific IgG Ab titers were induced in these transgenic mice. In contrast, spleen cells transferred into mice expressing the soluble form of VSV-G were not activated, and no VSV-G specific Abs were induced. These results indicate that highly immunogenic Ags are strongly tolerogenic for both immature B and T cells.

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