The correlation of telomerase and IL-10 with leukemia transformation in a mouse model of chronic lymphocytic leukemia (CLL).
- Authors
- Type
- Published Article
- Journal
- Leukemia Research
- Publisher
- Elsevier
- Publication Date
- Jun 01, 1998
- Volume
- 22
- Issue
- 6
- Pages
- 509–516
- Identifiers
- PMID: 9678717
- Source
- Medline
- License
- Unknown
Abstract
Telomerase activity is upregulated in activated and malignant lymphocytes. We studied the correlation of telomerase and IL-10 to leukemia transformation in the NZB mouse model of human chronic lymphocytic leukemia (CLL). Telomerase levels increased from early to late leukemic stages, likewise IL-10 gene expression levels increased with the leukemic progression. The inverse relationship of telomerase and IL-10 levels to the survival of NZB mice was also established. Our data suggested that telomerase and IL-10 were involved in transformation in the murine model of CLL and the detection of telomerase activities might be of value in the prediction of CLL progression.