Affordable Access

The correlation of telomerase and IL-10 with leukemia transformation in a mouse model of chronic lymphocytic leukemia (CLL).

Authors
  • Peng, B
  • Zhang, M
  • Sun, R
  • Lin, Y C
  • Chong, S Y
  • Lai, H
  • Stein, D
  • Raveche, E S
Type
Published Article
Journal
Leukemia Research
Publisher
Elsevier
Publication Date
Jun 01, 1998
Volume
22
Issue
6
Pages
509–516
Identifiers
PMID: 9678717
Source
Medline
License
Unknown

Abstract

Telomerase activity is upregulated in activated and malignant lymphocytes. We studied the correlation of telomerase and IL-10 to leukemia transformation in the NZB mouse model of human chronic lymphocytic leukemia (CLL). Telomerase levels increased from early to late leukemic stages, likewise IL-10 gene expression levels increased with the leukemic progression. The inverse relationship of telomerase and IL-10 levels to the survival of NZB mice was also established. Our data suggested that telomerase and IL-10 were involved in transformation in the murine model of CLL and the detection of telomerase activities might be of value in the prediction of CLL progression.

Report this publication

Statistics

Seen <100 times