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Correlation of survival motor neuron expression in leukocytes and spinal cord in spinal muscular atrophy.

Authors
  • Tsai, Li-Kai1
  • Yang, Chih-Chao
  • Ting, Chen-Hung
  • Su, Yi-Ning
  • Hwu, Wuh-Liang
  • Li, Hung
  • 1 Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. , (Taiwan)
Type
Published Article
Journal
The Journal of pediatrics
Publication Date
February 2009
Volume
154
Issue
2
Pages
303–305
Identifiers
DOI: 10.1016/j.jpeds.2008.08.050
PMID: 19150680
Source
Medline
License
Unknown

Abstract

Survival motor neuron (SMN) messenger RNA and protein levels in spinal muscular atrophy (SMA) model mice and in patients with SMA were measured. There was a high correlation between leukocyte and spinal cord SMN expression in SMA model mice and a moderate correlation between leukocyte SMN expression and age of disease onset in patients with SMA.

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