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Correlation of liver stiffness and histological features in healthy persons and in patients with occult hepatitis B, chronic active hepatitis B, or hepatitis B cirrhosis.

Authors
  • Fung, James
  • Lai, Ching-Lung
  • Chan, See-Ching
  • But, David
  • Seto, Wai-Kay
  • Cheng, Charles
  • Wong, Danny Ka-Ho
  • Lo, Chung-Mau
  • Fan, Sheung-Tat
  • Yuen, Man-Fung
Type
Published Article
Journal
The American Journal of Gastroenterology
Publisher
Springer Nature
Publication Date
May 01, 2010
Volume
105
Issue
5
Pages
1116–1122
Identifiers
DOI: 10.1038/ajg.2009.665
PMID: 19920809
Source
Medline
License
Unknown

Abstract

Liver stiffness measurement has an overall good diagnostic accuracy with excellent negative predictive value. However, in active CHB with elevated alanine aminotransferase (ALT) levels, the positive predictive value for diagnosing cirrhosis is poor, and further studies are needed to optimize the use of transient elastography in this important group.

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