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Correlation of enthesitis indices with disease activity and function in axial and peripheral spondyloarthritis: a cross-sectional study comparing MASES, SPARCC and LEI

Authors
  • Palominos, Penélope Esther1
  • de Campos, Ana Paula Beckhauser2
  • Ribeiro, Sandra Lúcia Euzébio3
  • Xavier, Ricardo Machado1, 4
  • Xavier, Jady Wroblewski4
  • de Oliveira, Felipe Borges4
  • Guerra, Bruno4
  • Saldanha, Carla1
  • Mancuso, Aline Castello Branco5
  • Kohem, Charles Lubianca1, 4
  • Gasparin, Andrese Aline1
  • Sampaio-Barros, Percival Degrava6
  • 1 Hospital de Clínicas de Porto Alegre, Serviço de Reumatologia, Ramiro Barcelos 2350, sexto andar, Porto Alegre, Rio Grande do Sul, CEP 90035-903, Brazil , Porto Alegre (Brazil)
  • 2 Hospital Universitário Evangélico, Serviço de Reumatologia, Alameda Augusto Stellfeld, 1908, Bigorrilho, Curitiba, Paraná, CEP 80730-150, Brazil , Curitiba (Brazil)
  • 3 Hospital Universitário Getúlio Vargas, Universidade Federal do Amazonas, Serviço de Reumatologia, Avenida Apurinã 4, Manaus, Amazonas, CEP 69020-170, Brazil , Manaus (Brazil)
  • 4 Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Ramiro Barcelos 2400, Porto Alegre, Rio Grande do Sul, CEP 90035-903, Brazil , Porto Alegre (Brazil)
  • 5 Hospital de Clínicas de Porto Alegre, Departamento de Bioestatística, Ramiro Barcelos 2350, Porto Alegre, Rio Grande do Sul, CEP 90035-903, Brazil , Porto Alegre (Brazil)
  • 6 Universidade de São Paulo, Serviço de Reumatologia, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, São Paulo, Brazil , São Paulo (Brazil)
Type
Published Article
Journal
Advances in Rheumatology
Publisher
BioMed Central
Publication Date
Jun 17, 2019
Volume
59
Issue
1
Identifiers
DOI: 10.1186/s42358-019-0066-8
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundThe presence of enthesitis is associated with higher disease activity, more disability and incapacity to work and a poorer quality of life in spondyloarthritis (SpA). There is currently no consensus on which clinical score should be used to assess enthesitis in SpA. The objective of the present work was to compare the correlation of three enthesitis indices (MASES, SPARCC and LEI) with measures of disease activity and function in a heterogeneous population of patients with axial and peripheral SpA.MethodsA cross-sectional study was conducted in three Brazilian public university hospitals; patients fulfilling ASAS classification criteria for peripheral or axial SpA were recruited and measures of disease activity and function were collected and correlated to three enthesitis indices: MASES, SPARCC and LEI using Spearman’s Correlation index. ROC curves were used to determine if the the enthesitis indices were useful to discriminate patients with active disease from those with inactive disease.ResultsTwo hundred four patients were included, 71.1% (N = 145) fulfilled ASAS criteria for axial SpA and 28.9% (N = 59) for peripheral SpA. In axial SpA, MASES performed better than LEI (p = 0.018) and equal to SPARCC (p = 0.212) regarding correlation with disease activity (BASDAI) and function (BASFI). In peripheral SpA, only MASES had a weak but statistical significant correlation with DAS28-ESR (rs 0.310 p = 0.05) and MASES had better correlation with functional measures (HAQ) than SPARCC (p = 0.034).ConclusionIn this sample composed of SpA patients with high coexistence of axial and peripheral features, MASES showed statistical significant correlation with measures of disease activity and function in both axial and peripheral SpA.

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