The NBNC patients with HCC had a higher frequency of non-cirrhotic liver without liver injury. The presence of the HBV-X gene in HCC suggests a possible role of past HBV infection in the development of HCC. About half of NBNC HCC is associated with seronegativity for HBsAg and positivity for the HBV-X gene in liver tissue.
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/12390472