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Correlation of clinical characteristics with detection of hepatitis B virus X gene in liver tissue in HBsAg-negative, and HCV-negative hepatocellular carcinoma patients.

Authors
  • Higashi, Yoichiro
  • Tada, Shuji
  • Miyase, Shuichi
  • Hirota, Kazuhiko
  • Imamura, Haruo
  • Kamio, Takihiro
  • Suko, Hironobu
Type
Published Article
Journal
Liver
Publication Date
Oct 01, 2002
Volume
22
Issue
5
Pages
374–379
Identifiers
PMID: 12390472
Source
Medline
License
Unknown

Abstract

The NBNC patients with HCC had a higher frequency of non-cirrhotic liver without liver injury. The presence of the HBV-X gene in HCC suggests a possible role of past HBV infection in the development of HCC. About half of NBNC HCC is associated with seronegativity for HBsAg and positivity for the HBV-X gene in liver tissue.

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