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Correlation between tumor oxygenation and 18F-fluoromisonidazole PET data simulated based on microvessel images.

Authors
  • Mönnich, David
  • Troost, Esther G C
  • Kaanders, Johannes H A M
  • Oyen, Wim J G
  • Alber, Markus
  • Zips, Daniel
  • Thorwarth, Daniela
Type
Published Article
Journal
Acta Oncologica
Publisher
Informa UK (Taylor & Francis)
Publication Date
Oct 01, 2013
Volume
52
Issue
7
Pages
1308–1313
Identifiers
DOI: 10.3109/0284186X.2013.812796
PMID: 23984808
Source
Medline
License
Unknown

Abstract

A combination of two FMISO PET scans acquired 0-15 min and four hours pi may yield an accurate measure of the medianPO2 in a voxel (FH/P). This measure is comparable to averaged oxygen probe measurements and has the advantage of covering the entire tumor volume. Therefore, it may improve the prediction of radiotherapy outcome and facilitate individualized dose prescriptions.

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