Affordable Access

Access to the full text

Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension

Authors
  • Özgüven, Salih1
  • Kesim, Selin1
  • Öksüzoğlu, Kevser1
  • Yanartaş, Mehmed2
  • Taş, Serpil2
  • Şen, Feyza1
  • Öneş, Tunç1
  • İnanır, Sabahat1
  • Turoğlu, Halil Turgut1
  • Mutlu, Bülent3
  • Erdil, Tanju Yusuf1
  • Yıldızeli, Bedrettin4
  • 1 Marmara University Pendik Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey
  • 2 University of Health Sciences Turkey, Kartal Koşuyolu Training and Research Hospital, Clinic of Cardiovascular Surgery, İstanbul, Turkey
  • 3 Marmara University Pendik Training and Research Hospital, Clinic of Cardiology, İstanbul, Turkey
  • 4 Marmara University Pendik Training and Research Hospital, Clinic of Thoracic Surgery, İstanbul, Turkey
Type
Published Article
Journal
Molecular Imaging and Radionuclide Therapy
Publisher
Galenos Publishing
Publication Date
Feb 09, 2021
Volume
30
Issue
1
Pages
28–33
Identifiers
DOI: 10.4274/mirt.galenos.2020.31932
PMID: 33586404
PMCID: PMC7885277
Source
PubMed Central
Keywords
License
Green

Abstract

Objectives: Chronic thromboembolic pulmonary hypertension (CTEPH) is a type of pulmonary hypertension with persistent pulmonary vascular obstruction and exercise intolerance, which may benefit from pulmonary endarterectomy (PEA). Ventilation/perfusion (V/Q) scan is the preferred screening test of CTEPH, which can be used to assess the anatomical extent of the disease. This study aimed to analyze the correlation between the extent of mismatched Q defects in V/Q single photon emission computed tomography/computed tomography (SPECT/CT) with preoperative clinical and hemodynamic parameters in patients with CTEPH. Methods: A total of 102 patients with CTEPH prior to PEA having V/Q SPECT/CT scans were retrospectively reviewed. Age, gender, New York Heart Association classification, intraoperative right-sided heart catheterization (mPAP and PVR), and 6-minute walk test (6MWT) findings were obtained from clinical records of patients. Results: Linear regression analysis showed a significant but weak correlation between the preoperative mPAP and PVR with the extent of mismatched Q defects in V/Q SPECT/CT (rs=0.09474 with p=0.0016 and rs=0.045 with p=0.045, respectively). No significant correlation was found between 6MWT and extent of mismatched Q defects in V/Q SPECT/CT (p>0.05). Conclusion: A quantitative assessment of Q defects on V/Q SPECT/CT might provide information about hemodynamic parameters in patients with CTEPH.

Report this publication

Statistics

Seen <100 times