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Correlation between loose density and compactibility of granules prepared by various granulation methods.

Authors
  • Murakami, H
  • Yoneyama, T
  • Nakajima, K
  • Kobayashi, M
Type
Published Article
Journal
International Journal of Pharmaceutics
Publisher
Elsevier
Publication Date
Mar 23, 2001
Volume
216
Issue
1-2
Pages
159–164
Identifiers
PMID: 11274817
Source
Medline
License
Unknown

Abstract

The objectives of this study were to prepare the lactose granules by various granulation methods using polyethylene glycol 6000 (PEG 6000) as a binder and to evaluate the effects of granulation methods on the compressibility and compactibility of granules in tabletting. Lactose was granulated by seven granulation methods -- four wet granulations including wet massing granulation, wet high-speed mixer granulation, wet fluidized bed granulation and wet tumbling fluidized bed granulation; and three melt granulations including melt high-speed mixer granulation, melt fluidized bed granulation and melt tumbling fluidized bed granulation. The loose density, angle of repose, granule size distribution, mean diameter of granules, and the tensile strength and porosity of tablets were evaluated. The compactibilities of granules were varied by the granulation methods. However, the difference in compactibility of granules could not be explained due to the difference in compressibility, since there was no difference in Heckel plots due to granulation methods. Among their granule properties, the loose density of granules seemed to have a correlation with the tablet strength regardless of the granulation methods.

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