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Correlation between Insulin-Like Growth Factor I and Skeletal Maturity Indicators

Authors
  • Carelli, Julia1, 2
  • Mattos, Camila1
  • Morais, Nathaly D.1
  • Scariot, Rafaela1
  • Brancher, João Armando1
  • Baratto-Filho, Flares1, 2
  • Kuchler, Erika Calvano1
  • Moro, Alexandre1
  • 1 Positivo University, Curitiba, Paraná, Brazil
  • 2 Univille - Universidade de Joinville, Joinville, Santa Catarina, Brazil
Type
Published Article
Journal
Global Pediatric Health
Publisher
SAGE Publications
Publication Date
Apr 29, 2021
Volume
8
Identifiers
DOI: 10.1177/2333794X211011305
PMID: 34017903
PMCID: PMC8114260
Source
PubMed Central
Keywords
Disciplines
  • Original Research Article
License
Unknown

Abstract

Objective: The purpose of this study was to evaluate the correlation between the growth maturity indicators in orthodontic patients. Design : This cross-sectional study was performed on 37 orthodontic patients (17 males and 20 females). An anamnesis, clinical and image examination, and blood sample collection were performed. The inclusion criteria were non-syndromic Class II patients of both gender, age ranging between 10 to 16 years. The lateral cephalometric radiographs were evaluated using 6-stage cervical vertebrae maturation (CVM) technique. The hand-wrist radiographs were staged using the 11-stage skeletal maturation indicator (SMI) technique. Blood was collected in the same week of the images to quantify IGF-1 levels in serum. Data were tested for normality by Shapiro–Wilk test. The Pearson test was used to determine the correlation strength between the variables (alpha of 5%). Results : A strong correlation was observed only between SMI stages and CVM stages in the total sample (r=0.864; p<0.0001) and according to the gender (r=0.793; p<0.0001 for females; and r=0.753; p<0.0001 for males). IGF-1 was only moderately correlated with SMI stages and CVM stages. Conclusion : Hand-wrist and cervical vertebral stages were strongly correlated among them, however, IGF-1 was only moderately correlated with both skeletal maturity indicators.

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