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Correlation between endoscopic and histological validated scoring indices in Crohn's disease.

Authors
  • Gong, Wenbin1
  • Guo, Kun2
  • Zheng, Tao2
  • Fang, Miao3
  • Xie, Haohao3
  • Li, Weijie3
  • Hong, Zhiwu2
  • Ren, Huajian2
  • Gu, Guosheng2
  • Wang, Gefei2
  • Wu, Xiuwen2
  • Wang, Zhiming4
  • Ren, Jianan5
  • Li, Jieshou2
  • 1 School of Medicine, Southeast University, Department of General Surgery, Jinling Hospital, PR China. , (China)
  • 2 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, PR China. , (China)
  • 3 Department of General Surgery, Jinling Hospital, Nanjing Medical University, PR China. , (China)
  • 4 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, PR China. Electronic address: [email protected] , (China)
  • 5 Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, PR China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Publication Date
Jun 01, 2019
Volume
51
Issue
6
Pages
812–817
Identifiers
DOI: 10.1016/j.dld.2019.01.010
PMID: 30718202
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

It is of crucial importance to evaluate disease activity by means of endoscopy and histopathology in Crohn's disease (CD). Nonetheless, correlation between endoscopic and histological validated indices has not been verified. We aim to correlate the Simple Endoscopic Score for Crohns disease (SES-CD) with two validated widely used histological indices in patients with established CD. The SES-CD at the worst affected area was scored and histological disease activity using Global Histologic Disease Activity Score (GHAS or D'Haens score) and the Naini and Cortina Score (NCS) was scored independently by two pathologists blinded to the clinical information and endoscopic results. Spearman correlation between the SES-CD, GHAS and NCS were performed. 143 patients, 32 with SES-CD scores 0-2, 57 with 3-6, 37 with 7-15, and 17 with ≥16. Correlation coefficients between SES-CD and GHAS were r = 0.86 (95% CI 0.80-0.91, p < 0.001) and between SES-CD and NCS r = 0.85 (95% CI 0.81-0.88, p < 0.001). There was a strong correlation between the two histological indices (r = 0.70, 95% CI 0.59-0.78, p < 0.001). Mucosal healing without histological disease activity was most correlated with SES-CD score 0 or 1. The SES-CD strongly correlates with both GHAS and NCS. The SES-CD of 0 to 1 best represents histological remission that correlates with quiescent disease activity. Copyright © 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

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