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Correlation between Diabetes Mellitus and Knee Osteoarthritis: A Dry-To-Wet Lab Approach

Authors
  • Dubey, Navneet Kumar
  • Ningrum, Dina Nur Anggraini
  • Dubey, Rajni
  • Deng, Yue-Hua
  • Li, Yu-Chuan
  • Wang, Peter D.
  • Wang, Joseph R.
  • Syed-Abdul, Shabbir
  • Deng, Win-Ping
Publication Date
Oct 03, 2018
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

0.0001) was noted. Further, histopathologic and Western blot studies of diabetic mice knee joints revealed enhanced carboxymethyl lysine (advanced glycation end product), matrix metalloproteinase-1, and reduced cartilage-specific proteins, including type II collagen (Col II), SOX9, and aggrecan (AGN), indicating deteriorated articular cartilage and proteoglycans. Results indicate that DM is strongly associated with KOA, and obesity may not be a confounding factor.

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