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Correlation of 18F-FDG/PET SUV max, SUV mean, MTV, and TLG with HIF-1α in Patients with Colorectal Cancer

Authors
  • Kaymak, Zümrüt Arda1
  • Karahan, Nermin2
  • Erdoğan, Mehmet3
  • Erdemoğlu, Evrim4
  • Zihni, İsmail5
  • Şengül, Sevim Süreyya3
  • 1 Süleyman Demirel University Faculty of Medicine, Department of Radiaiton Oncology, Isparta, Turkey
  • 2 Süleyman Demirel University Faculty of Medicine, Department of Pathology, Isparta, Turkey
  • 3 Süleyman Demirel University Faculty of Medicine, Department of Nuclear Medicine, Isparta, Turkey
  • 4 Süleyman Demirel University Faculty of Medicine, Department of Gynecologic Oncology, Isparta, Turkey
  • 5 Süleyman Demirel University Faculty of Medicine, Department of Surgical Oncology, Isparta, Turkey
Type
Published Article
Journal
Molecular Imaging and Radionuclide Therapy
Publisher
Galenos Publishing
Publication Date
Jun 03, 2021
Volume
30
Issue
2
Pages
93–100
Identifiers
DOI: 10.4274/mirt.galenos.2021.04934
PMID: 34082509
PMCID: PMC8185477
Source
PubMed Central
Keywords
Disciplines
  • Original Article
License
Unknown

Abstract

Objectives: Post-hypoxia hypoxia-inducible factor (HIF)-1α activation plays a vital role in colorectal cancer (CRC) angiogenesis. Although glucose metabolism is induced in some cancer types via HIF-1α, the prognostic significance of HIF-1α in CRC and its correlation with 18fluorinefluorodeoxyglucose (18F-FDG) uptake in positron emission tomography (PET) remain controversial. This study aims to investigate the association between 18F-FDG/PET parameters and HIF-1α expression in CRC. Methods: Thirty-six histopathologically confirmed patients with CRC who had 18F-FDG/PET scans before surgery were enrolled in the study. The correlations between the maximum standardized uptake value (SUVmax), SUVmean, metabolic tumor volume (MTV), total lesion glycolysis, HIF-1α overexpression, and histopathological features were evaluated. Results: The tumor location, tumor diameter, perineural invasion, lymphovascular invasion, T and N stage were not significantly correlated with HIF-1α overexpression. In contrast, the tumor differentiation was negatively correlated with HIF-1α expression (r=-0.332, p=0.048). None of the 18F-FDG/PET parameters was significantly correlated with HIF-1α overexpression. A significant relationship was found between tumor differentiation, tumor necrosis percentage, and MTV (p=0.030, p=0.020). Conclusion: The expected association between HIF-1α overexpression and 18F-FDG/PET parameters was not found in this study. However, there was a relationship between MTV, tumor differentiation, and tumor necrosis percentage. Hence, further studies are required to predict the pathological and prognostic courses of CRC using a diagnostic 18F-FDG/PET evaluation.

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