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Correlated expression of human beta defensin-1, -2 and -3 mRNAs in gingival tissues of young children

Authors
  • Saitoh, Masato
  • Abiko, Yoshihiro
  • Shimabukuro, Shintaro
  • Kusano, Kaoru
  • Nishimura, Michiko
  • Arakawa, Toshiya
  • Nakashima, Keisuke
  • Takuma, Taishin
  • Kaku, Tohru
  • Igarashi, Seiji
Type
Published Article
Journal
Archives of Oral Biology
Publisher
Elsevier
Publication Date
Jan 01, 2004
Accepted Date
Apr 19, 2004
Volume
49
Issue
10
Pages
799–803
Identifiers
DOI: 10.1016/j.archoralbio.2004.04.012
Source
Elsevier
Keywords
License
Unknown

Abstract

Objective: Human β-defensins (hBDs) are a group of antimicrobial peptides, expressed by the epithelial cells of many organs including gingival epithelium. The present study examined correlation between the gene expressions of hBD-1, -2, -3 mRNAs and the inflammatory cytokines in human gingival tissues. Study design: The gingival tissues were obtained from surgical discards from 20 different patients (age range, 5–13 years). The expression levels of mRNAs were evaluated by quantitative RT-PCR with LightCycler™. The mRNA expression levels were normalized with those of keratin 10 mRNA. The data were statistically analysed using Person’s correlation coefficient. Results: The expression levels of hBD-1,-2 and -3 were significantly correlated with each other and also correlated with that of TNF-α. Conclusions: The results indicate that the expression levels of hBDs vary from one individual to another.

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