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Coronary heart disease outcomes among chronic opioid and cyclooxygenase-2 users compared with a general population cohort.

Authors
  • Carman, Wendy J
  • Su, Shuhua
  • Cook, Suzanne F
  • Wurzelmann, John I
  • McAfee, Andrew
Type
Published Article
Journal
Pharmacoepidemiology and drug safety
Publication Date
Jul 01, 2011
Volume
20
Issue
7
Pages
754–762
Identifiers
DOI: 10.1002/pds.2131
PMID: 21567652
Source
Medline
License
Unknown

Abstract

Chronic analgesic use with either COT or COX-2 was associated with an increased risk of cardiovascular outcomes. These findings suggest either a selection of high-risk patients to chronic analgesic treatment, coupled with unmeasured or residual confounding, or a potential cardiovascular effect of these medications. Further research is warranted to evaluate causes for this association.

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