Affordable Access

Access to the full text

Cord Blood Levels of EPA, a Marker of Fish Intake, Correlate with Infants’ T- and B-Lymphocyte Phenotypes and Risk for Allergic Disease

Authors
  • Barman, Malin
  • Rabe, Hardis1
  • Hesselmar, Bill
  • Johansen, Susanne
  • Sandberg, Ann-Sofie
  • Wold, Agnes E.1
  • 1 (A.E.W.)
Type
Published Article
Journal
Nutrients
Publisher
MDPI AG
Publication Date
Sep 30, 2020
Volume
12
Issue
10
Identifiers
DOI: 10.3390/nu12103000
PMID: 33007868
PMCID: PMC7601506
Source
PubMed Central
Keywords
License
Green

Abstract

Maternal fish intake during pregnancy has been associated with reduced allergy development in the offspring and here, we hypothesized that components of fish stimulate fetal immune maturation. The aim of this study was to investigate how maternal fish intake during pregnancy and levels of n-3 long-chain polyunsaturated fatty acids (LCPUFAs) in the infant’s cord serum correlated with different subsets of B- and T-cells in cord blood and B-cell activating factor (BAFF) in cord plasma, and with doctor-diagnosed allergy at 3 and 8 years of age in the FARMFLORA birth-cohort consisting of 65 families. Principal component analysis showed that infant allergies at 3 or 8 years of age were negatively associated with the proportions of n-3 LCPUFAs (eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) in infant cord serum, which, in turn correlated positively with maternal fish intake during pregnancy. Both maternal fish intake and cord serum n-3 LCPUFAs correlated negatively to CD5+ B cells and the FOXP3+CD25high of the CD4+ T cell subsets in cord blood, but not to BAFF in cord plasma. Our observational study suggests that fish might contain components that promote maturation of the infant’s immune system in a manner that protects against allergy development.

Report this publication

Statistics

Seen <100 times