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Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study.

Authors
  • McGrath, Lauren M1
  • Yu, Dongmei2
  • Marshall, Christian3
  • Davis, Lea K4
  • Thiruvahindrapuram, Bhooma3
  • Li, Bingbin3
  • Cappi, Carolina5
  • Gerber, Gloria6
  • Wolf, Aaron6
  • Schroeder, Frederick A6
  • Osiecki, Lisa6
  • O'Dushlaine, Colm7
  • Kirby, Andrew6
  • Illmann, Cornelia6
  • Haddad, Stephen6
  • Gallagher, Patience6
  • Fagerness, Jesen A6
  • Barr, Cathy L8
  • Bellodi, Laura9
  • Benarroch, Fortu10
  • And 101 more
  • 1 Massachusetts General Hospital, Boston; American University, Washington, DC; Harvard-MIT Broad Institute, Boston.
  • 2 Massachusetts General Hospital, Boston; Harvard-MIT Broad Institute, Boston.
  • 3 University of Toronto and the Hospital for Sick Children, Toronto.
  • 4 University of Chicago.
  • 5 University of São Paulo Medical School.
  • 6 Massachusetts General Hospital, Boston.
  • 7 Harvard-MIT Broad Institute, Boston.
  • 8 University of Toronto and the Hospital for Sick Children, Toronto; Toronto Western Research Institute, University Health Network, Toronto.
  • 9 Università Vita-Salute San Raffaele, Milan.
  • 10 Hadassah-Hebrew University Medical Center, Jerusalem.
  • 11 Johns Hopkins University School of Medicine, Baltimore.
  • 12 University of Iowa College of Medicine, Iowa City.
  • 13 Yale University School of Medicine, New Haven, CT.
  • 14 North Shore-Long Island Jewish Medical Center, New Hyde Park, NY; New York University Medical Center, New York.
  • 15 North Shore-Long Island Jewish Medical Center, New Hyde Park, NY; Hofstra University School of Medicine, Hempstead, NY.
  • 16 Instituto Nacional de Psiquiatría Ramon de la Fuente Muñiz, Mexico. , (Mexico)
  • 17 Utrecht University and VU Medical Center, Amsterdam.
  • 18 Ospedale San Raffaele, Milan.
  • 19 University of Montreal.
  • 20 Robert Debre University Hospital, Paris and the French National Science Foundation, Creteil, France; Institut Pasteur, Paris. , (France)
  • 21 Netherlands Institute for Neuroscience, Amsterdam; Academic Medical Center, Amsterdam. , (Netherlands)
  • 22 Academic Medical Center, Amsterdam.
  • 23 Federal University of São Paulo.
  • 24 University of New South Wales, Australia. , (Australia)
  • 25 University of Munich.
  • 26 Hospital Nacional de Niños, San Jose, Costa Rica; Clinica Herrera Amighetti, Avenida Escazú, San José, Costa Rica. , (Costa Rica)
  • 27 University Medicine Greifswald, Greifswald, Germany. , (Germany)
  • 28 Brown Medical School, Providence, RI.
  • 29 Shaare Zedek Medical Center, Jerusalem.
  • 30 University of Zurich.
  • 31 Rutgers University, Piscataway Township, NJ.
  • 32 University of Stellenbosch, South Africa. , (South Africa)
  • 33 Hospital Nacional de Niños, San Jose, Costa Rica. , (Costa Rica)
  • 34 Baylor College of Medicine, Houston.
  • 35 Centre for Addiction and Mental Health, Toronto.
  • 36 Atlantic Neuroscience Institute, Summit, NJ.
  • 37 Carracci Medical Group, Mexico City. , (Mexico)
  • 38 Robert Debre University Hospital, Paris and the French National Science Foundation, Creteil, France; Institut Mondor de Recherche Biomédicale, Créteil, France. , (France)
  • 39 University of Bonn, Germany. , (Germany)
  • 40 University of California at San Francisco School of Medicine.
  • 41 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
  • 42 University of California, Irvine.
  • 43 University of California, Los Angeles (UCLA) School of Medicine.
  • 44 University of Utah, Salt Lake City.
  • 45 National Institute of Mental Health (NIMH) Intramural Research Program, Bethesda, MD.
  • 46 Medical City Dallas Hospital.
  • 47 Zilkha Neurogenetic Institute, Los Angeles.
  • 48 University of Toronto and the Hospital for Sick Children, Toronto; Sunnybrook Health Sciences Centre, Toronto.
  • 49 University College London.
  • 50 Wayne State University and Detroit Medical Center, Detroit.
  • 51 Montreal Neurological Institute.
  • 52 University of Cologne, Germany. , (Germany)
  • 53 Federal University of São Paulo; Universidade Federal da Bahia, Salvador, Bahia, Brazil. , (Brazil)
  • 54 VU Amsterdam and Erasmus University Medical Centre, Rotterdam; VU University Amsterdam; VU Medical Center, Amsterdam.
  • 55 University of Cape Town, South Africa. , (South Africa)
  • 56 Vanderbilt University, Nashville, TN.
  • 57 University of Zurich; University of Würzburg.
  • 58 Erasmus Medical Center Rotterdam, the Netherlands. , (Netherlands)
  • 59 German Center for Neurodegenerative Diseases, Bonn and VU Medical Center Amsterdam.
  • 60 University of California, Los Angeles (UCLA) School of Medicine; Semel Institute for Neuroscience and Human Behavior, UCLA.
  • 61 VU Amsterdam and Erasmus University Medical Centre, Rotterdam.
  • 62 University of Michigan, Ann Arbor, MI.
  • 63 Massachusetts General Hospital, Boston; University of British Columbia, Vancouver.
  • 64 University of Illinois at Chicago.
  • 65 Massachusetts General Hospital, Boston; Brigham and Womens Hospital, Boston; Harvard-MIT Broad Institute, Boston. Electronic address: [email protected]
Type
Published Article
Journal
Journal of the American Academy of Child and Adolescent Psychiatry
Publication Date
August 2014
Volume
53
Issue
8
Pages
910–919
Identifiers
DOI: 10.1016/j.jaac.2014.04.022
PMID: 25062598
Source
Medline
Keywords
License
Unknown

Abstract

Several converging lines of evidence implicate 16p13.11 deletions in OCD, with weaker evidence for a role in TS. The trend toward increased overall neurodevelopmental CNV burden in TS and OCD suggests that deletions previously associated with other neurodevelopmental disorders may also contribute to these phenotypes.

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