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Copper-Catalyzed Self-Condensation of Benzamide: Domino Reactions towards Quinazolinones

Authors
  • SAYYAD, N
  • CELE, Z
  • ALETI, RR
  • BERA, M
  • CHERUKUPALLI, S
  • CHANDRASEKARAN, B
  • KUSHWAHA, ND
  • KARPOORMATH, R
Publication Date
Dec 03, 2018
Source
DSpace at IIT Bombay
Keywords
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Unknown
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Abstract

We herein report a simple and highly efficient microwave-assisted, copper-catalyzed and ligand-free synthetic method for 2-substituted 4(3H)-quinazolinones as domino reaction. This reaction proceeds via self-condensation of substrate (2-bromo/iodo benzamide) in the presence of a strong base and copper catalyst. The substituted quinazolinones were obtained in one-pot reaction by intramolecular cyclization (condensation) via Ullmann-type intermediate. Both the intermediates and quinazolinones were obtained in good yield and can be further used as building blocks for developing the potential novel drug-like compounds.

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