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Copper-mediated C-H bond arylation of arenes with arylboronic acids.

Authors
Type
Published Article
Journal
Organic Letters
1523-7052
Publisher
American Chemical Society
Publication Date
Volume
10
Issue
16
Pages
3607–3609
Identifiers
DOI: 10.1021/ol8013717
PMID: 18613691
Source
Medline
License
Unknown

Abstract

A new copper-mediated cross-coupling of arenes and arylboronic acids is described. Under the influence of Cu(OCOCF 3) 2, the C-H bond arylation of electron-rich arenes with arylboronic acids takes place to afford a range of biaryls in good yields. The reaction is selective for cross-coupling; no homocoupling product arising from arenes or arylboronic acids is detected. Multiple C-H bond arylation is possible with indoles and pyrroles furnishing interesting extended pi-systems.

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