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Copper-catalyzed trifluoromethylation-cyclization of enynes: highly regioselective construction of trifluoromethylated carbocycles and heterocycles.

Authors
  • Gao, Pin
  • Yan, Xiao-Biao
  • Tao, Tao
  • Yang, Fan
  • He, Ting
  • Song, Xian-Rong
  • Liu, Xue-Yuan
  • Liang, Yong-Min
Type
Published Article
Journal
Chemistry - A European Journal
Publisher
Wiley (John Wiley & Sons)
Publication Date
Oct 18, 2013
Volume
19
Issue
43
Pages
14420–14424
Identifiers
DOI: 10.1002/chem.201303025
PMID: 24114879
Source
Medline
Keywords
License
Unknown

Abstract

Regioselective trifluoromethylation-cyclization: A method for copper-catalyzed trifluoromethylation-cyclization of simple enynes using the CC triple bond as a nucleophile is reported for the first time. The reaction proceeds efficiently in a highly regioselective manner to give various 5- or 6-exo-dig carbocycles and heterocycles in moderate to high yields.

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