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Copper-catalyzed oxidative amination of sp(3) C-H bonds under air: synthesis of 1,3-diarylated imidazo[1,5-a]pyridines.

Authors
  • Wang, Huiqiao
  • Xu, Wentao
  • Wang, Zhiqiang
  • Yu, Lintao
  • Xu, Kun
Type
Published Article
Journal
The Journal of Organic Chemistry
Publisher
American Chemical Society
Publication Date
Feb 20, 2015
Volume
80
Issue
4
Pages
2431–2435
Identifiers
DOI: 10.1021/jo5027723
PMID: 25629877
Source
Medline
License
Unknown

Abstract

A copper(II)-catalyzed tandem reaction between pyridine ketone and benzylamine was developed by using clean O2 as an oxidant. This transformation proceeded via an efficient condensation-amination-oxidative dehydrogenation process, affording 1,3-diarylated imidazo[1,5-a]pyridines in excellent yields.

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