Affordable Access

Coordinated regulation of amino sugar-synthesizing and -degrading enzymes in Escherichia coli K-12.

Authors
  • J A Plumbridge
  • O Cochet
  • J M Souza
  • M M Altamirano
  • M L Calcagno
  • B Badet
Publication Date
Aug 01, 1993
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

The intracellular concentration of the enzyme glucosamine-6-phosphate synthase, encoded by the gene glmS in Escherichia coli, is repressed about threefold by growth on the amino sugars glucosamine and N-acetylglucosamine. This regulation occurs at the level of glmS transcription. It is not due just to the presence of intracellular amino sugar phosphates, because mutations which derepress the genes of the nag regulon (coding for proteins involved in the uptake and metabolism of N-acetylglucosamine) also repress the expression of glmS in the absence of exogenous amino sugars.

Report this publication

Statistics

Seen <100 times