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Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation.

Authors
  • Xing, Yue1, 2, 3, 4
  • Tench, Christopher5
  • Wongwandee, Monton6
  • Schwarz, Stefan T7, 8
  • Bajaj, Nin9
  • Auer, Dorothee P10, 11, 12, 13
  • 1 Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, NG7 2UH, UK. [email protected]
  • 2 Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, NG7 2UH, UK. [email protected]
  • 3 NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, NG7 2UH, UK. [email protected]
  • 4 Radiological Sciences, Sir Peter Mansfield Imaging Centre, NIHR Nottingham BRC, University of Nottingham, Nottingham, NG7 2UH, UK. [email protected]
  • 5 Division of Clinical Neurology, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
  • 6 Department of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand. , (Thailand)
  • 7 Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, NG7 2UH, UK.
  • 8 Department of Radiology, Cardiff and Vale University Health Board, Cardiff, Wales.
  • 9 Department of Neurology, Nottingham University Hospitals, Nottingham, NG7 2UH, UK.
  • 10 Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, NG7 2UH, UK. [email protected]
  • 11 Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, NG7 2UH, UK. [email protected]
  • 12 NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, NG7 2UH, UK. [email protected]
  • 13 Radiological Sciences, Sir Peter Mansfield Imaging Centre, NIHR Nottingham BRC, University of Nottingham, Nottingham, NG7 2UH, UK. [email protected]
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Aug 01, 2020
Volume
14
Issue
4
Pages
1263–1280
Identifiers
DOI: 10.1007/s11682-019-00061-3
PMID: 30809759
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To investigate factors affecting the pattern of motor brain activation reported in people with Parkinson's (PwP), aiming to differentiate disease-specific features from treatment effects. A co-ordinate-based-meta-analysis (CBMA) of functional motor neuroimaging studies involving patients with Parkinson's (PwP), and healthy controls (HC) identified 126 suitable articles. The experiments were grouped based on subject feature, medication status (onMed/offMed), deep brain stimulation (DBS) status (DBSon/DBSoff) and type of motor initiation. HC and PwP shared similar neural networks during upper extremity motor tasks but with differences of reported frequency in mainly bilateral putamen, insula and ipsilateral inferior parietal and precentral gyri. The activation height was significantly reduced in the bilateral putamen, left SMA, left subthalamus nucleus, right thalamus and right midial global pallidum in PwPoffMed (vs. HC), and pre-SMA hypoactivation correlated with disease severity. These changes were not found in patients on dopamine replacement therapy (PwPonMed vs. HC) in line with a restorative function. By contrast, left SMA and primary motor cortex showed hyperactivation in the medicated state (vs. HC) suggesting dopaminergic overcompensation. Deep-brain stimulation (PwP during the high frequency subthalamus nucleus (STN) DBS vs. no stimulation) induced a decrease in left SMA activity and the expected increase in the left subthalamic/thalamic region regardless of hand movement. We further demonstrated a disease related effect of motor intention with only PwPoffMed showing increased activation in the medial frontal lobe in self-initiated studies. We describe a consistent disease-specific pattern of putaminal hypoactivation during motor tasks that appears reversed by dopamine replacement. Inconsistent reports of altered SMA/pre-SMA activation can be explained by task- and medication-specific variation in intention. Moreover, SMA activity was reduced during STN-DBS, while dopamine-induced hyperactivation of SMA which might underpin hyperdynamic L-dopa related overcompensation.

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