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Conversional studies towards taxoids from C(19)-diterpenoid alkaloids by the BAC sequence.

Authors
  • Ji, Hong
  • Chen, Qiao-Hong
  • Zhu, Meng
  • Wang, Feng-Peng
Type
Published Article
Journal
Journal of Asian natural products research
Publication Date
Nov 01, 2010
Volume
12
Issue
11
Pages
968–977
Identifiers
DOI: 10.1080/10286020.2010.510796
PMID: 21061219
Source
Medline
License
Unknown

Abstract

The conversional synthesis of taxoids by the BAC sequence from the C(19)-diterpenoid alkaloids, 14-acetyltalatisamine (1), yunaconitine (12), and 14-acetylchasmanine (19), was designed and explored. Two aconane-type diterpenes 17 and 28, the advanced intermediates for our conversional synthesis, were synthesized. The key steps include the rupture of the C(7)-C(17) bond, the formation of imine, and the denitrogenation.

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