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Convergent synthesis of a fully phosphorylated GPI anchor of the CD52 antigen.

Authors
  • Wu, Xiaoming1
  • Guo, Zhongwu
  • 1 Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, USA.
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Oct 11, 2007
Volume
9
Issue
21
Pages
4311–4313
Identifiers
PMID: 17877362
Source
Medline
License
Unknown

Abstract

A fully phosphorylated GPI anchor (1) of the CD52 antigen was synthesized by a highly convergent strategy. After a trimannose and a phospholipidated pseudodisaccharide were prepared separately, they were coupled together to form the GPI core, which was then phosphorylated to introduce two phosphoethanolamine moieties in one step to afford CD52 GPI in its fully protected form. Finally, global deprotection of the product resulted in 1.

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